COVID-19 MOLECULAR AND CLINICAL ASPECTS
Dr. Sadaf Ali
Author / Research Scholar
About the Author(s)
Dr. Sadaf Ali has completed her MBBS and then did her MD in Biochemistry. She was topper of batch both in her MBBS and MD in her university. She rmly believes that Medicine is incomplete without a good clinical research. All the aspects of pathology need to be correlated at the molecular basis. Every disease has a different molecular aspects and different pathological aspects that are nally manifested clinically as a wide spectrum of signs and symptoms. Therefore, work at molecular level by doing clinical research may help us to prevent various deleterious effects due to a particular disease. She has worked on a number of research projects and has 14 publications in her credit. In addition to this she has 13 book chapters in her name published in various inte ational and national books. Most of these are afliated to Springer, Elsevier, Taylor and Francis and Web of science, Index Medicus. She has worked on Diabetes Mellitus and its molecular aspects like advanced glycation end products. Her work also consists on Hepatobiliary Research and various aspects of Covid-19. Currently she is working on Ferritin levels in hepatobiliary diseases.
Synopsis & Scholarly Abstract
Covid-19 is a novel strain of corona virus that emerged in China in December 2019. This soon led to a global pandemic in a short span of time. Study of the molecular structure of Covid-19 may aid in development of therapeutic measures.2 Due to Covid-19 pandemic there is always an extraordinary risk to health and healthcare systems globally.3 Covid-19 usually manifests with the signs and symptoms of respiratory illness, cough usually dry cough, fever, associated with myalgias and sometimes breathing difculties. This is mainly due to decrease in oxygen saturation rates in these patients. Although some people show fever with body aches whilst some are relatively asymptomatic. Corona virus is primarily transmitted in humans through respiratory route and is highly contagious. Mostly old people and those having co-morbid illnesses suffered most. Corona viruses are made of single stranded RNA present within the coat. The virus has a diameter of nearly 80 nm to 120 nm. After invading into the human body, the virus may lead to a sequence of processes such as viral invasion, replication, and programmed cell death i.e. apoptosis. In depth studies on the molecular aspects of Covid-19 in detail may help to design therapeutic agents as well as for vaccine formation. The micro-RNA is dened as the single- stranded non-coding RNA molecules.12 They have length of about 22 nucleotides approximately and help in post transcriptional regulation of gene expression.12, 13 Micro RNAs are believed to regulate many types of cancers also in addition to Covid-19 and other infections.