PROLONGED EFFECTS OF MEMORY ENHANCING DRUG ON CHOLINERGIC AND ATPase SYSTEMS
Dr. Kalyani Bai Kunte
Author / Research Scholar
About the Author(s)
Dr. Kalyani Bai Kunte is a qualied professional and having experience in Environmental Biology, Coastal & Marine Biology, Aquaculture and Fisheries, Wetlands and Mangrove ecosystems, Medicinal Plants etc., and having Doctorate in Zoology (Animal Sciences) with specialization in the area of Neurobiology and applied research on Nootropic plants and their therapeutic uses. Dr. Kalyani Bai Kunte is having 16 years of teaching and Research experience in different domains of biological sciences. She also presented her Research works in National and Inte ational seminars. She also worked in the prestigious UNDP-GEF-GoI project as Project Scientist and contribute her scientic knowledge in successful implementation of the project and presently working as Research Scientist in APSBB, EFS&T Dept. Govt. of Andhra Pradesh, India. She has published about 18 Research papers / articles in reputed Inte ational Jou als with good Impact Factor. She has published two books and associated in preparation of ve Action plans / Management Plans / Biodiversity Friendly sector plans. Her professional experience and contribution in mainstreaming the biodiversity conservation in different production sectors received appreciations also. she was the Eminent Scientist Awardee for the year 2023 honored from NESA, New Delhi and CSIR-NBRI, Lucknow.
Synopsis & Scholarly Abstract
The increasing longevity of the human population is accompanied by a rise in the incidence of neurodegenerative conditions such as Alzheimer's disease (AD). This disease accounts 70 % of dementia causes in most industrialized countries and is characterized by cell atrophy and extensive neuronal loss. According to National Institutes of Health, an estimated 8.5 million Americans will develop AD by the year 2030. It is the fourth leading cause of death in United States. The disease may span several decades if the preclinical period is included. Various strategies have been investigated to cure AD, but the use of cholinesterase inhibitor drugs has been the most clinically successful. The main function of these drugs is to improve the memory power, hence also called as memory enhancing drugs. Memory enhancement therapy can be viewed as generally benecial to many individuals, not only those whose ability to function on a day basis has been compromised. For various reasons, however, drugs potentially useful as memory or cognition enhancers are exclusively being developed to treat patients with dementia. It has been observed that many of the health drinks known as memory boosters such as Brain Speed Shake, Brain Speed Smoothie, Mocha Focus Delight etc., have substances whose chemical structure is very similar to the memory enhancing drugs viz. Galantanine hydrobromide which is widely used for treating the Alzheimer's disease. This has given an idea to take up the present study. In the present investigation, Galantamine hydrobromide, a memory enhancing drug which is a cholinesterase inhibitor has been chosen to assess its prolonged effects on some selected physiological and biochemical parameters in the skeletal muscle of albino mice during normal conditions of health. This book comprises of ve chapters and mainly studied the impact of memory enhancing drug on Cholinergic system and ATPase activities in different regions of skeletal muscle of albino mice under prolonged treatment.